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Sequence alignment of HypA and HypA homologue proteins from various bacteria. Black boxes represent strictly conserved residues, red boxes show the two conserved CxxC motifs and blue boxes depict the alignment with the flanking His residue from H. pylori. H. pylori HypA is 53%, 22%, 25%, 20% identical and 77%, 48%, 51%, 56% similar to HypA homologues from H. hepaticus, E. coli, and T. kodakaraensis, respectively.
