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. Author manuscript; available in PMC: 2010 Sep 7.
Published in final edited form as: Transplantation. 2008 Mar 15;85(5):675–680. doi: 10.1097/TP.0b013e3181663422

FIGURE 2.

FIGURE 2

Anti-CD45RB-mediated tolerance is disrupted by blockade of intercellular adhesion molecule (ICAM)-1 or LFA-1. Hearts from C3H mice were transplanted into the abdominal cavity of B6 mice. (A) Mice were untreated (n=9, square) or treated with anti-CD45RB Abs (100 μg intraperitoneally [IP] on days 0, 1, 3, 5, 7; n=15, diamond), anti-ICAM-1 (50 μg IP for 7 days; n=6, triangle), anti-LFA-1 (50 μg for 7 days; n=6, circle), or the combination of anti-ICAM-1/anti-LFA-1 (n=6, inverted triangle). Tolerance was induced in both anti-CD45RB (P<0.0001 vs. untreated) and ICAM-1/LFA-1 combination therapy recipients (P<0.0001 vs. untreated). (B) Coadministration of anti-CD45RB with anti-ICAM-1 (n=8, triangle), anti-LFA-1 (n=8, circle), and anti-LFA-1/ICAM-1 (n=5, inverted triangle) combination abrogated tolerance induction in all cases. The untreated and anti-CD45RB-tolerized groups from (A) are shown for comparison (square).