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. Author manuscript; available in PMC: 2010 Sep 7.
Published in final edited form as: Transplantation. 2008 Mar 15;85(5):675–680. doi: 10.1097/TP.0b013e3181663422

FIGURE 3.

FIGURE 3

Anti-CD45RB is ineffective in mice that lack expression of intercellular adhesion molecule (ICAM)-1 or LFA-1. Hearts from C3H donors were transplanted heterotopically into the abdominal cavity of B6 mice that were genetically deficient in ICAM-1 or LFA-1 expression. Transplantation of C3H hearts into either ICAM-1−/− (n=6, triangle) or LFA-1−/− (n=6, diamond) recipients leads to rejection in a routine fashion indicating the immunocompetence of the recipients. Treatment of ICAM-1−/− (n=8, open triangle) or LFA-1−/− (n=6, open diamond) deficient animals with anti-CD45RB therapy is unable to induce tolerance in either case although there is a modest prolongation over untreated animals.