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. Author manuscript; available in PMC: 2010 Sep 7.
Published in final edited form as: Transplantation. 2008 Mar 15;85(5):675–680. doi: 10.1097/TP.0b013e3181663422

FIGURE 4.

FIGURE 4

Expression of intercellular adhesion molecule (ICAM)-1 by B lymphocyte is required for tolerance induction. B-cell-deficient B6 hosts were reconstituted with B lymphocytes by intravenous injection of 10 million splenocytes from normal B6 donors. B-lymphocyte-deficient hosts were resistant to tolerance induction by anti-CD45RB (n=10, diamond), and tolerance was restored by transfer of splenocytes from normal B6 donors (n=7, triangle; P<0.001 vs. anti-CD45RB-treated B-deficient control). However, reconstitution with ICAM-1-deficient cells (n=12, circle) was unable to restore tolerance induction.