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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2010 Jul 27;18(18):6748–6755. doi: 10.1016/j.bmc.2010.07.054

Figure 1.

Figure 1

Protein-ligand interactions in the substrate-binding site of human GDA. (A) Guanine-hGDA interactions. (B) Xanthine-hGDA interactions. Two-dimensional representation of ligand–protein interactions were analyzed using Ligplot [54]. Hydrogen bonds formed between protein residues and ligands are indicated by dashed green lines and the corresponding distance (Å) and residues engaged in hydrophobic interactions are represented in red.