Fig. 6.
Increase in glutamate receptor permeability shifted the BCM-like plasticity profile to the left. A: percentage weight change induced by 900 pulses of stimuli at various frequencies plotted as a function of the stimulus frequency for various values of AMPA receptor (AMPAR) permeability. A progressive leftward shift in the BCM-like plasticity profile may be noted with increase in AMPAR permeability. B: plotting the modification threshold, θm, as a function of AMPAR permeability indicates an approximately linear relationship between the 2, until the compartment starts eliciting spikes (point denoted by an arrow). C: plotting θm as a function of NMDAR permeability suggests a similar relationship. The plot is shown for various values of AMPAR permeability. All red arrows indicate the point at which compartment switched from generating an EPSP to generating a spike.