Fig. 8.

Flupenthixol but not metoclopramide blocked DA effects on LP I_A. The STG was sequentially exposed to the following treatments: a 10 min, 10⁻⁵ M DA application, a 30 min wash, a 5 min, 10⁻⁵ M antagonist application, and a 10 min antagonist + DA application. A given preparation received one antagonist, either flupenthixol (□, n = 5) or metoclopramide (■, n = 5). LP I_A was recorded at the end of each treatment and immediately before DA application. The change from baseline was plotted for V_1/2 activation (A) and V_1/2 inactivation (B). Measurements from recordings prior to DA application served as the baseline for DA and wash treatments. Measurements from the wash served as baseline for subsequent treatments. *, significant difference from DA alone (n = 5) as determined with 1 way ANOVAs followed by Tukey post hoc tests.