Table 1.
List of drugs tested to screen DAR antagonists
| Drugs |
|---|
| (−)-Butaclamol |
| Clozapine |
| Sulpiride |
| Haloperidol |
| Spiperone HCl |
| Methiothepin mesylate |
| Metoclopramide |
| Cyproheptadine HCl |
| N-R(+)-SCH 23390 |
| Chlorpromazine |
| (+)-Butaclamol |
| Domperidone |
| Eticlopride |
| Fluphenazine 2HCI |
| Flupenthixol |
Three criteria were used to select an antagonist: ability to block interval pyloric and pyloric dilator IA; effects on dopamine receptors (DARs) expressed in a heterologous expression system; effects on parental cell lines. Based on these criteria, we chose the best two drugs to examine in detail (flupenthixol and metoclopramide). We have not excluded the possibility that other drugs listed here are effective antagonists for lobster DARs.