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. 2010 Jun 16;104(2):922–931. doi: 10.1152/jn.00413.2010

Fig. 3.

Fig. 3.

Cocaine pre-exposure for 1 day does not alter rapid dopamine responses in the NAc core or shell after an acute cocaine challenge. A: rapid dopamine responses in the NAc core after application of various stimulation frequencies to the VTA (n = 9). Dopamine responses are represented as concentration vs. time for both the predrug state (gray trace) and after an acute cocaine challenge (black trace). Both pre-exposure groups showed an increase in [DA]max after acute cocaine at all frequencies tested (*P < 0.05 vs. baseline, 1-sample t-test), with the exception of the 20-Hz response in the saline-treated subjects (+P < 0.07 vs. baseline, 1-sample t-test). No significant differences were observed when comparing acute cocaine responses in 1-day saline vs. 1-day cocaine-treated subjects (P > 0.05, independent samples t-test). B: rapid dopamine responses in the NAc shell after application of various stimulation frequencies to the VTA (n = 16). Both 1-day saline- and 1-day cocaine-treated subjects showed increased [DA]max after an acute cocaine challenge at all frequencies tested (*P < 0.05, 1-sample t-test), with no difference between the two treatment groups (P > 0.05, 1-sample t-test). [DA]max data presented as ±SE.