Fig. 6.
Cocaine pre-exposure for 7 days leads to a greater uptake inhibition during an acute cocaine challenge. A: 1-day saline- and cocaine-treated subjects showed increased [DA]p in response to an acute cocaine challenge (*P < 0.05 vs. baseline, **P < 0.005 vs. baseline, ***P < 0.001 vs. baseline, 1-sample t-test). B: all groups also showed a significant increase in apparent Km after the acute cocaine challenge (*P < 0.05 vs. baseline, **P < 0.005 vs. baseline, 1-sample t-test) with the exception of the NAc core response in 1-day cocaine subjects. In addition, 7-day cocaine-treated subjects showed a potentiated change in apparent Km while cocaine was on board, as shown by a main effect of cocaine (F3,25 = 5.942, *P < 0.05, univariate ANOVA). Data presented as ±SE.