TABLE 1.

Antibiotic susceptibility of P. aeruginosa in the presence or absence of 32 μg/ml of ME1071

Organism (no. of isolates tested) and antibiotic	ME1071a	MIC (μg/ml)			% Sa	% Ra
		Range	MIC50	MIC90
MBL-producing P. aeruginosa (174)
Piperacillin	−	0.5->128	>128	>128	34	66
	+	1->128	128	>128	37	63
Ceftazidime	−	2->64	>64	>64	6	94
	+	2->64	32	>64	33	53
Aztreonam	−	0.25->128	32	128	9	63
	+	0.5->128	32	128	8	64
Imipenem	−	0.5->64	>64	>64	8	88
	+	0.5->64	16	>64	17	75
Meropenem	−	0.5->64	>64	>64	6	86
	+	0.25->64	16	>64	14	72
Biapenem	−	0.12->64	>64	>64	7	86
	+	0.12->64	8	>64	22	40
Doripenem	−	0.25->64	>64	>64	8	80
	+	0.25->64	8	>64	20	50
Non-MBL-producing P. aeruginosa (16)
Piperacillin	−	4->128	>128	>128	19	81
	+	4->128	>128	>128	25	75
Ceftazidime	−	2->64	16	64	25	50
	+	2->64	16	64	25	44
Aztreonam	−	4->128	32	>128	13	56
	+	4->128	32	>128	13	56
Imipenem	−	1-32	16	32	13	88
	+	1-32	16	32	13	81
Meropenem	−	0.12-64	16	64	25	56
	+	0.25-64	16	64	19	56
Biapenem	−	0.5-32	16	32	13	69
	+	0.5-32	16	32	13	63
Doripenem	−	0.25-32	8	32	31	44
	+	0.25-32	8	32	38	44
IMP-1-producing P. aeruginosa (166)
Piperacillin	−	0.5->128	>128	>128	34	66
	+	1->128	128	>128	37	63
Ceftazidime	−	2->64	>64	>64	7	93
	+	2->64	32	>64	33	52
Aztreonam	−	0.25->128	32	128	7	64
	+	0.5->128	32	128	7	64
Imipenem	−	0.5->64	>64	>64	8	87
	+	0.5->64	16	>64	17	75
Meropenem	−	0.5->64	>64	>64	6	86
	+	0.25->64	16	>64	13	72
Biapenem	−	0.12->64	>64	>64	8	86
	+	0.12->64	8	32	22	38
Doripenem	−	0.25->64	>64	>64	8	80
	+	0.25->64	8	>64	20	49
VIM-2-producing P. aeruginosa (8)
Piperacillin	−	64->128	128	>128	38	63
	+	16->128	128	>128	38	63
Ceftazidime	−	32->64	64	>64	0	100
	+	4->64	32	>64	38	63
Aztreonam	−	8-128	16	128	38	50
	+	8->128	32	>128	38	63
Imipenem	−	16->64	>64	>64	0	100
	+	2->64	64	>64	13	75
Meropenem	−	16->64	>64	>64	0	100
	+	1->64	32	>64	25	75
Biapenem	−	8->64	64	>64	0	75
	+	0.25->64	16	>64	25	75
Doripenem	−	16->64	64	>64	0	100
	+	1->64	16	>64	25	63

^aClinical and Laboratory Standards Institute (CLSI) (2010) breakpoints, where available (1), were used. CLSI (2010) does not have criteria (susceptible, intermediate, or resistant) for biapenem or doripenem (1). For comparison only, the same values for imipenem (CLSI, 2010) were used as criteria for biapenem and doripenem. S, susceptible; R, resistant.