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Kinetic parameters of the purified IMP-1 and VIM-2 enzymes
| Compound | IMP-1 |
VIM-2 |
||||
|---|---|---|---|---|---|---|
| kcat (s−1) | Km or Ki (μM) | kcat/Km (μM−1 s−1) | kcat (s−1) | Km or Ki (μM) | kcat/Km (μM−1 s−1) | |
| Imipenem | 63.5 ± 1.2 | 35.1 ± 3.8 | 1.8 | 98.9 ± 0.7 | 8.5 ± 0.5 | 12 |
| Meropenem | NDa | ND | 0.2 | 8.5 ± 0.3 | 9.4 ± 0.9 | 0.9 |
| Biapenem | 44.7 ± 4.7 | 167 ± 21 | 0.3 | 12.4 ± 0.3 | 24.7 ± 0.5 | 0.5 |
| ME1071b | 0.41 ± 0.1 | 120 ± 3.8 | ||||
ND, not determined.
Ki value.
