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. 2010 Jun 28;54(9):3590–3596. doi: 10.1128/AAC.00115-10

TABLE 1.

β-Lactams administered to patients receiving and not receiving aminoglycosides as empirical therapy

Antibiotic No.a (%; n = 4,863) No. (%) receiving:
OR (95% CI) P
Combination therapy (n = 678) β-Lactam only (n = 4,185)
Ampicillin 380 (8) 43 (6) 377 (8) 0.8 (0.5-1.1) 0.1
Amoxicillin-clavulanate 249 (5) 3 (0.4) 246 (6) 0.1 (0.02-0.2) <0.0001
Non-antipseudomonal cephalosporin 2,490 (51) 117 (17) 2,373 (57) 0.2 (0.1-0.3) <0.0001
Antipseudomonal cephalosporin 354 (7) 186 (27) 168 (4) 9 (7-11) <0.0001
Piperacillin-tazobactam 979 (20) 156 (23) 863 (20) 1.2 (1-1.5) 0.04
Antipseudomonal carbapenem 761 (16) 185 (27) 576 (14) 2.4 (2-3) <0.0001
a

In 350 episodes, more than one β-lactam was administered(ampicillin plus a cephalosporin in 76% of these cases).