TABLE 1.
Comparison of PK parameters of levofloxacin in common marmosets, rhesus monkeys, and humans
| Species (dose) | t1/2 (h) | tmax (h) | Cmax (μg/ml) | AUCINF obs (μg/liter/h) | Reference |
|---|---|---|---|---|---|
| Marmoseta (40 mg/kg) | 2.3 | 0.5 | 20.9 | 81.4 | This study |
| Human (500 mg) | 7.6 | 1.1 | 5.7 | 47.5 | 3 |
| Human (500 mg) | 6.4 | 1.5 | 8.5 | 56.3 | 2 |
| Rhesus monkey (15 + 4 mg/kg)c | 3.4b | 2.2b | 5.3b | 33.4b | 15 |
| Rhesus monkey (15 mg/kg) | 2 | 1.5b | 5.1b | 21.3b | 12 |
a
Day 7 data from the multidose study.
b
Mean of male and female data.
c
A 15-mg/kg dose was followed by a 4-mg/kg dose administered 12 h later.