TABLE 1.
Levels of ampC expression after incubation of P. aeruginosa PAO1
| Condition (concn [μg/ml])a | Mean ampC expression ± SDb |
|---|---|
| Basal (no antibiotic) | 1 |
| FOX (50) | 50 ± 14 |
| CAZ | |
| 1/4 MIC (0.25) | 1.2 ± 0.2 |
| 1/2 MIC (0.5) | 1.2 ± 0.3 |
| CXA | |
| 1/4 MIC (0.125) | 1.6 ± 1.3 |
| 1/2 MIC (0.25) | 1.3 ± 0.7 |
| IMP | |
| 1/4 MIC (0.25) | 193.2 ± 20.2 |
| 1/2 MIC (0.5) | 269.5 ± 73.1 |
a
P. aeruginosa PAO1 was incubated in the presence of subinhibitory concentrations of CXA-101 (CXA), ceftazidime (CAZ), imipenem (IMP), and cefoxitin (FOX) as indicated.
b
The relative amount of ampC mRNA compared to the PAO1 basal level is given.