TABLE 2.
Posaconazole concentrations in plasma, ELF, and AC
| Parameter | Value for time (h) group: |
||||
|---|---|---|---|---|---|
| 3 (n = 4) | 5 (n = 5) | 8 (n = 4) | 12 (n = 4) | 24 (n = 4) | |
| Time to blood draw (h) | 2.8 ± 0.6 | 4.5 ± 1.0 | 8.7 ± 0.9 | 11.8 ± 0.4 | 21.1 ± 3.2 |
| Time to BAL (h) | 3.2 ± 0.7 | 5.3 ± 1.0a | 9.1 ± 0.7 | 12.1 ± 0.9 | 22.4 ± 3.0 |
| Plasma (μg/ml) | 1.3 ± 0.4 | 1.1 ± 1.4 | 0.81 ± 0.49 | 0.93 ± 0.56 | 0.74 ± 0.61 |
| ELF (μg/ml) | 1.1 ± 0.7 | 1.3 ± 1.7b | 1.0 ± 0.8c | 1.2 ± 1.2 | 0.5 ± 0.3 |
| ELF/plasma ratio | 0.94 | 0.57 | 0.90 | 1.0 | 0.68 |
| AC (μg/ml) ratio | 55.4 ± 44.0 | 31.3 ± 25.4b | 54.7 ± 58.8 | 36.8 ± 30.8 | 49.6 ± 62.1 |
| AC/plasma ratio | 40.7 | 27.3 | 63.6 | 53.3 | 56.4 |
a
One subject in the 5-h group underwent bronchoscopy but did not complete the BAL.
b
The ELF and AC calculations in this group are based on an n of 3.
c
The ELF sample from one subject was lost in transit; this ELF calculation is based on an n of 3.