TABLE 3.

Model independent pharmacodynamic parameters in plasma, ELF, and AC

Parameter	Value
	Plasma	ELF	AC
AUC0-12 (μg/ml·h−1)	10.99	11.21	530.2
AUC0-12/MIC90	19.95	18.42	1,162
AUC0-24 (μg/ml·h−1)	21.98	22.42	1,060
AUC0-24/MIC90	39.90	36.84	2,324
12-h Cmax (μg/ml)	1.3 ± 0.4	1.3 ± 1.7	55.4 ± 44.0
12-h Cmax/MIC90	2.5	2.6	110.8
12-h Tmax	2.8 ± 0.6	5.3 ± 1.0	3.2 ± 0.7
12-h Cmin (μg/ml)	0.81 ± 0.49	1.0 ± 0.8	31.3 ± 25.4
T > MIC90 (h)	24	24	24