TABLE 1.
Distribution of pfmdr1 polymorphisms in day 0 and day-of-failure samplesa
| Sample group | Amino acid at position: |
n | |
|---|---|---|---|
| 86 | 184 | ||
| Day 0 samples | N | Y | 29 |
| N | F | 12 | |
| Y | F | 7 | |
| Y | Y | 1 | |
| F | Y | 1 | |
| Day-of-failure samples | N | Y | 13 |
| N | F | 10 | |
| Y | F | 5 | |
| Y | Y | 2 | |
| F | Y | 3 | |
a
Genotype changes occurred at codons 86 and 184 only. The 86N allele (wild type) was found in 82.0% of pretreatment samples and 69.7% of posttreatment samples (P = 0.29 by Fisher's exact test). The prevalence of 184Y decreased from 62.0% of pretreatment samples to 54.5% of posttreatment samples (P = 0.65 by Fisher's exact test). None of the changes showed statistically significant evidence of selection. The sequences at codons 1034 (S), 1042 (N), and 1246 (D) were wild type both before and after treatment with AQ.