TABLE 2.

ORs for nasopharyngeal carriage of S. pneumoniae and H. influenzae from mixed-effects logistic regression models with the child as a random effect^a

Characteristic	Carriage of S. pneumoniae		Carriage of H. influenzae
	OR (95% CI)c	P	OR (95% CI)	P
Unadjusted ORs for probability of carriage over timeb
CoT arm vs placebo arm at randomization	0.78 (0.53-1.16)	0.22	0.72 (0.46-1.13)	0.16
Change per 52 wks in placebo arm	1.09 (0.80-1.48)	0.58	0.82 (0.57-1.17)	0.27
Change per 52 wks in CoT arm	1.63 (1.23-2.16)	0.001	1.09 (0.80-1.50)	0.59
Test for comparison of change in carriage over time between CoT and placebo		0.06		0.24
Univariable ORs for other factors adjusted for time and treatment arm
Per 10% higher CD4% at time of specimen	0.96 (0.78-1.16)*	0.65	1.14 (0.89-1.47)	0.29
Per 10% greater decrease CD4% from baseline at time of specimen	0.79 (0.40-1.54)*	0.49	0.97 (0.45-2.08)	0.93
Age (yr) of child at specimen
≤3	1.00		1.00
>3	1.13 (0.83-1.55)	0.44	1.28 (0.88-1.87)	0.19
Sex of child
Female	1.00		1.00
Male	0.87 (0.67-1.11)	0.26	0.84 (0.63-1.12)	0.24
Period (mo) during which specimen was taken
Dec-Feb	1.00		1.00
Mar-May	1.17 (0.83-1.65)	0.36	1.96 (1.30-2.98)	0.001
Jun-Aug	1.42 (0.99-2.05)	0.06	1.57 (1.01-2.45)	0.05
Sep-Nov	1.12 (0.78-1.60)	0.54	2.26 (1.48-3.48)	<0.001

^aAll ORs are adjusted for time from randomization and treatment arm.

^bChanges in the probability of carriage over time estimated separately for placebo and CoT treatment arms, without adjustment for any other factors.

^c*, Estimated from fixed-effects logistic regression since mixed models estimating the effect of CD4% and CD4% change from the baseline on the carriage of S. pneumoniae were unstable.