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ICP0-BMAL1 complex enhances transcription of mRNA from the reporter gene containing BMAL1 response elements. COS-7 cells were transfected with the M34 reporter plasmid and pRSV-LacZ in combination with expression plasmid as indicated. Luciferase activity was assayed in cells that were harvested 48 h after transfection as described in Materials and Methods. Luciferase activity were normalized with that of β-galactosidase. The results represent averages of three independent experiments.
