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Resistance of replicon cells selected with BMS-790052. Pooled populations of replicon cells selected for resistance to BMS-790052 at the indicated concentrations were assayed for sensitivity to BMS-790052 and an HCV NS3 PI. Fold resistance was plotted as the EC50 of inhibitor on the resistant cells divided by the EC50 on DMSO-treated control cells. Error bars are standard deviations for three assays.
