TABLE 1.
Potency and selection concentration of BMS-790052 on replicon cell lines
| Genotype | Cell culture-adaptive mutation | EC50a (pM) (n) | Selection concn (pM, unless shown otherwise) |
|---|---|---|---|
| 1b | S2204I | 5.5 ± 4.3 (11) | 50, 100, 500 |
| ΔS2197 | 12.3 ± 8.5 (5) | 200 | |
| R2884G | 9.0 ± 3.2 (4) | 200 | |
| 1a | P1496L and S2204I | 49.4 ± 27.1 (5) | 200, 1 nM, 1 μM |
| 1b1a100b | S2204I | 25.4 ± 2.7 (2) | 200, 1 nM |
a
Mean ± standard deviation, determined with the parental cell line.
b
Hybrid 1b replicon with first 100 amino acids of NS5A from genotype 1a.