TABLE 2.
Frequencies of NS5A amino acid substitutions in cDNA clones isolated from BMS-790052-treated genotype 1b replicon cellsa
| Amino acid substitution | No. of clones at indicated BMS-790052 concn |
Total no. of clones | ||||
|---|---|---|---|---|---|---|
| S2204I cells |
ΔS2197 cells, 200 pM | R2884G cells, 200 pM | ||||
| 50 pM | 100 pM | 500 pM | ||||
| L31F | 2 | 1 | 1 | 4 | ||
| L31V | 1 | 5 | 10 | 5 | 21 | |
| P32L | 1 | 1 | ||||
| P58S | 1 | 1 | ||||
| I63V | 1 | 1 | ||||
| Y93H | 10 | 8 | 7 | 3 | 6 | 34 |
| Y93N | 1 | 1 | ||||
| Y93S | 1 | 1 | ||||
| L23F + L31F | 2 | 2 | ||||
| R30Q + L31F | 3 | 3 | ||||
| L31V + Y93C | 1 | 1 | ||||
| L31V + Y93H | 2 | 1 | 1 | 4 | ||
| L31V + Y93N | 1 | 1 | ||||
| F37L + Y93H | 1 | 1 | 2 | |||
| Q54H + Y93H | 1 | 1 | ||||
| None | 1 | 1 | ||||
| Total | 15 | 13 | 18 | 16 | 17 | 79 |
a
Replicon cells are described in Table 1.