TABLE 3.

Rifampin population pharmacokinetic model parameter values^a

Parameterb	Result (mean ± SD) for each treatment arm		P value
	4SR/4CR	8SR
CL (liters/h/1.85 m2)	24.1 ± 9.8	37.3 ± 5.5	0.17
V (liters/kg LBMc)	1.19 ± 0.21	1.43 ± 0.10	0.17
ka (h−1)	0.998 ± 1.35	0.807 ± 0.574	0.83
Tlag (h)	2.07 ± 0.55	1.52 ± 0.86	0.44

^aOral bioavailability was fixed at a value of 1 for both treatment arms.

^bLBMc, lean body mass; k_a, absorption rate constant; T_lag, lag time; the other abbreviations are defined in the text.