TABLE 2.
In vitro antibacterial activities of amphibian CAMPs on the MDR strain of P. aeruginosaa
| Peptide | Concn (μM) for antibacterial activity |
||
|---|---|---|---|
| MIC | Bactericidal activityb |
||
| MHB | PBS | ||
| Temporin-1Tb | >64 | >64 | >64 |
| Temporin-1Tf | >64 | >64 | >64 |
| Temporin-1Tl | 64 | >64 | 16 |
| Esc(1-18) | 8 | 64 | 16 |
| Esc(1-21) | 4 | 16 | 4 |
a
Resistance phenotype: ampicillin, cefepime, cefotaxime, ceftazidime, cefuroxime, ciprofloxacin, gentamicin, meropenem, piperacillin, tobramycin, trimethoprim-sulfamethoxazole.
b
The bactericidal activity is expressed as the concentration of peptide that is sufficient to reduce the number of viable bacteria by ≥3 log10 CFU/ml after 90 min of incubation.