TABLE 1.

MICs for isavuconazole, posaconazole, voriconazole, and fluconazole against rare yeast pathogens obtained using the CLSI broth microdilution assay and the Etest

Isolate (n = 74)	Procedure	Isavuconazole				Posaconazole				Voriconazole				Fluconazole
		MIC (μg/ml)			Pa	MIC (μg/ml)			P	MIC (μg/ml)			P	MIC (μg/ml)			P
		MIC50	MIC90	Range		MIC50	MIC90	Range		MIC50	MIC90	Range		MIC50	MIC90	Range
D. capitatusb	CLSI	0.06	0.5	≤0.015-0.5	NSc	0.125	0.5	≤0.015-1	NS	0.06	0.25	≤0.015-0.5	0.003	4	16	0.25-32	0.001
	Etest	0.125	1	≤0.015-1		0.06	0.5	≤0.015-1		0.03	0.06	≤0.015-0.06		1	4	≤0.125-8
R. mucilaginosad	CLSI	0.5	2	0.125-2	0.001	1	8	0.25->16	<0.001	2	8	0.5-8	<0.001	>128	>128	>128	NS
	Etest	1	4	0.25-4		>16	>16	>16		>16	>16	8->16		>128	>128	>128
S. cerevisiaee	CLSI	0.03	0.5	≤0.015-1	0.016	1	2	0.06-2	0.001	0.125	0.25	0.03-0.5	0.001	4	16	1-32	NS
	Etest	0.125	0.5	0.03-2		2	>16	≤0.015->16		0.03	0.125	≤0.015-0.125		4	64	0.5->128
Trichosporon spp.f	CLSI	0.06	0.5	≤0.015-0.5	NS	0.125	0.25	0.03-0.25	NS	0.06	0.25	≤0.015-0.25	0.005	2	8	≤0.125-8	NS
	Etest	0.06	0.125	≤0.015-0.125		0.125	0.5	≤0.015-0.5		0.03	0.125	≤0.015-0.125		1	4	0.03-4
Overall	CLSI	0.125	0.5	≤0.015-2	0.001	0.5	2	≤0.015->16	<0.001	0.125	2	≤0.015-8	NS	4	>128	≤0.125->128	NS
	Etest	0.125	2	≤0.015-4		0.5	>16	≤0.015->16		0.06	>16	≤0.015->16		2	>128	≤0.125->128

^aDifferences in the antifungal susceptibilities obtained by CLSI and Etest procedures reached statistical significance for P values of <0.05.

^bMICs for 1 D. capitatus isolate were read after 3 days (CLSI) or 4 days (Etest) of incubation due to poor fungal growth.

^cNS, nonsignificant.

^dMICs for 2 R. mucilaginosa isolates were read after 7 days (CLSI and Etest) due to poor fungal growth.

^eMICs for 5 S. cerevisiae isolates were read after 5 days (CLSI) due to poor fungal growth.

^fMICs for 3 Trichosporon isolates were read after 3 days (CLSI) or 4 days (Etest) due to poor fungal growth.