Table 2.
Parameter | C (n=4) | HF (n=7) | HF + NAC (n=8) |
---|---|---|---|
Cellular Injury | 0.0 ± 0.0a | 0.9 ± 0.1b | 0.9 ± 0.1b |
Hepatocellular Ballooning | 0.0 ± 0.0a | 2.0 ± 0.4c | 1.1 ± 0.3b |
Lobular Inflammation | 0.6 ± 0.2a | 1.3 ± 0.2b | 1.1 ± 0.1b |
Lipidosis (Oil Red O Staining) | 0.8 ± 0.2a | 3.5 ± 0.2b | 3.7 ± 0.2b |
Total Score | 1.4 ± 0.3a | 8.1 ± 0.6c | 7.0 ± 0.4b |
Total Score - Lipidosis | 0.6 ± 0.3a | 4.6 ± 0.6c | 3.3 ± 0.3b |
Fibrosis (Picosirius Red Staining) | 3.6 ± 0.6a | 17 ± 2.8c | 7.2 ± 1.9b |
The pathology calculation was based on our previously published system for pathology scoring (15). Values are means ± SEM. Means in a row without a common letter differ, p≤0.05.