Figure 2. Development of chronic autoimmne thrombocytopenia in a patient who presented initially with thrombocytopenia caused by sulfamethoxazole (SMX)-dependent, platelet-reactive antibodies.
SMX-dependent antibodies were identified in acute phase serum together with GPIIb/IIIa-specific non-drug-dependent autoantibodies. Persistent non-drug-dependent antibodies reactive with autologous platelets were identified during Weeks 1, 5, and 9. SMX = sulfamethoxazole; ICH = intracranial hemorrhage; IVIgG = intravenous gamma globulin. From RH Aster, 2000 [38] with permission of the publisher.