Fig. 6.

Histopathologic analysis for type I collagen in the liver after CCl₄ administration in ob/ob mice and their lean littermates. Representative photomicrographs of (A) CCl₄-treated male lean littermates of ob/ob mice and (B) CCl₄-treated ob/ob mice. Simultaneous treatment with vehicle (saline and olive oil) is also shown in C for the lean littermates and D for ob/ob mice. These photomicrographs represent 3 independent studies in which 4 male mice were included in each treatment group (picrosirius red stain, original magnification 100×).