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. Author manuscript; available in PMC: 2010 Sep 7.
Published in final edited form as: Biochim Biophys Acta. 2009 Jun 17;1789(9-10):558–570. doi: 10.1016/j.bbagrm.2009.06.001

Figure 5.

Figure 5

Structure of Domains II, III and IV of the HCV IRES. (A) Domain II (PDB accession code 1P5P) is annotated to show nucleotides that are conserved in HCV, pestivirus and several picornavirus HCV-like IRESs. (C) Domain IIId (PDB accession code 1F84) is annotated to show the conserved apical GGG motif, in which GG266–267 are exposed to the minor groove and G268 is in the major groove. (B) The nomenclature of domains and helices is as in [53].