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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Bioorg Med Chem. 2009 Aug 12;17(19):6993–7001. doi: 10.1016/j.bmc.2009.08.011

Table 1.

NOE correlations for compounds 21-30 in DMSO-d6.

Cmpd Proton shift (δH ppm) NOE Correlation (δH ppm)
Ring
Aa 		Ring Bb Phenyl
ring(s)
21 c 1.99 (s, 3H, CH3) 6.43
(s, 2H)		 6.50 (dd, 1H, J = 8.1
Hz, J = 2.0 Hz)
6.56 (d, 1H, J = 2.0 Hz)
22 d 1.97 (s, 3H, CH3) 6.58 (dd, 1H, J = 8.0
Hz, J = 2.0 Hz)
6.59 (d, 1H, J = 2.0 Hz)		 7.22 (d,
2H, J = 7.2
Hz)
23 d 0.88 (t, 3H, J = 7.2 Hz,
CH2CH3) and 2.33 (q,
2H, J = 7.2 Hz, CH2CH3)		 6.45
(s, 2H)		 6.50 (dd, 1H, J = 8.3
Hz, 2.2 Hz)
6.56 (d, 1H, J = 2.2 Hz)
24 d 0.87 (t, 3H, J = 7.2 Hz,
CH2CH3) and 2.30 (q,
2H, J = 7.2 Hz, CH2CH3)		 6.56 (dd, 1H, J = 7.9
Hz, 1.8 Hz)
6.57 (d, 1H, J = 1.8 Hz)		 7.23 (d,
2H, J = 6.8
Hz)
25 d 6.18 (s, 2H, ArH) 7.02-7.16
(m, 10H)
26 d 6.25 (s, 2H, ArH) 6.54 (dd, 1H, J = 8.3
Hz, 2.1 Hz)
6.62 (d, 1H, J = 2.0 Hz)		 7.00-7.12
(m, 10H)
27 c 2.11 (s, 3H, CH3) 6.37
(s, 2H)		 6.59 (d, 1H, J = 2.0 Hz)
6.63 (dd, 1H, J = 8.2
Hz, 2.0 Hz)
28 c 2.03 (s, 3H, CH3) 6.43
(s, 2H)		 7.19 (m,
2H)
29 c 0.92 (t, 3H, J = 7.4 Hz,
CH2CH3) and 2.48 (q,
2H, J = 7.4 Hz, CH2CH3)		 6.34
(s, 2H)		 6.59 (d, 1H, J = 2.0 Hz),
6.63 (dd, 1H,
J = 8.2 Hz, J = 2.0 Hz,)
30 c 0.89 (t, 3H, J = 7.4 Hz,
CH2CH3) and 2.37 (q,
2H, J = 7.4 Hz, CH2CH3)		 6.40
(s, 2H)		 7.18 (d,
2H, J = 7.0
Hz)
a

3,4,5-trimethoxyphenyl ring

b

3′-hydroxy-4′-methoxyphenyl ring

c

data determined at 500 MHz

d

data determined at 360 MHz