Figure 2.

Amino-acid sequence alignment of the icosahedral lumazine synthases from B. anthracis, B. subtilis, A. aeolicus and S. oleracea with two pentameric lumazine synthases from M. tuberculosis and C. albicans. The numbering corresponds to the enzyme from B. anthracis. The secondary-structure elements are shown below the sequences as they are found in BaLS. The residues highlighted in yellow and cyan are involved in the formation of the active site and the binding of inhibitors, respectively. The part of the structure which is responsible for the formation of the icosahedral assembly is highlighted in magenta.