Table 1.

Table 1a: Definition of volumetric MRI measures and their correlation with EDSS
Measure	Definition	rho	p
GD	Gadolinium-enhancing lesion volume (cc)	0.147	0.101
BOD	“Burden of Disease” T2-hyperintense lesion volume (including T1-lesion component) (cc)	0.276	< 0.002
BH	“Black Hole” T1-hypointense lesion volume (cc)	0.298	< 0.001
nCSF	Ratio of CSF volume to total intracranial volume	0.221	0.013

Table 1b. Definition of relaxation MRI measures and their correlation with EDSS
Measure	Definition	rho	p
T2-GM	Mean T2 value of gray matter (ms)	0.188	0.035
T2-WM	Mean T2 value of white matter (ms)	0.109	0.224
T2-LES	Mean T2 value of T2-hyperintense lesions (excluding T1-lesion component) (ms)	0.126	0.161
T2-BH	Mean T2 value of T1-lesions (ms)	0.294	< 0.001