. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: Mult Scler. 2010 Sep;16(9):1117–1125. doi: 10.1177/1352458510374892

Table 3. Definition of various composite z-scores and correlation to EDSS.

Score	Definition	rho	p
Z4f	(Z_BOD + Z_BH + Z_nCSF) + Z_T2BH	0.344	< 0.0001
Z3d	(Z_BH + Z_nCSF) + (Z_T2BH)	0.344	< 0.0001
Z3c	(Z_BOD + Z_nCSF) + (Z_T2BH)	0.341	< 0.0001
Z3e	Z_BOD + Z_BH + Z_nCSF (volumetry)	0.337	0.0001
Z2a	Z_BOD + Z_nCSF (volumetry)	0.325	< 0.001
Z4a^†	Z_GD + Z_BOD + Z_BH + Z_nCSF (volumetry)	0.322	< 0.001
Z4c	Z_T2GM + Z_T2WM + Z_T2LES + Z_T2BH (relaxation)	0.221	<0.05

^†

Used in the North American Linomide Trial, see reference [24].