Fig. 3.
DKO mice demonstrate increased apoptosis following acute ethanol treatment. Representative sagittal sections depicting ethanol-induced apoptosis in the striatum 4 hours after 2.5 g/kg (A, C) or 5.0 g/kg (B, D) in P7 WT and DKO mice. DKO mice demonstrated 2.5 fold increases in activated caspase-3 expression compared to WT mice (*, p < 0.05) at both doses (C, 2.5 g/kg; D, 5.0 g/kg).