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ACKO mice demonstrate increased apoptosis following acute ethanol treatment. Representative sagittal sections depicting ethanol-induced apoptosis in the striatum 4 hours after 5.0 g/kg (A) in P7 WT, DKO, AC1KO and AC8KO mice. AC1KO, AC8KO and DKO mice demonstrated statistically equivalent levels of activated caspase-3 expression in the striatum, which were significantly increased compared to WT mice (B, *, p < 0.05) after ethanol exposure.
