Table I.

Estimated values of blood half-lives for the Db-DIII and Db

Protein	Blood AUCa	First Mob (h)	MRTc (h)
Db-DIII WT	1449	178	56.7
Db-DIII H535A	470	66	25
Db-DIII H510A	528	38	20
Db-DIII H464A	354	24	17
Db	104	26	2.9

^aAUC is the area under the curve −∫u(t)dt from 0 to infinity.

^bFirst Mo is the first moment: ∫t u(t)dt/∫u(t)dt, where u(t) is the measured (%ID/g) blood curve.

^cMRT is the same integral format except du/dt replaces u(t).