Table II.

Biodistribution, showing the ¹²⁴I-labeleled Db-DIII proteins in descending order (top to bottom), in terms of their persistence in the circulation (blood %ID/g)

Protein	Organ/tissue (%ID/g) at 51 h
	Blood	Liver	Spleen	Kidneys	Lungs	LS174T (+)	C6 (−)	Carcass
Db-DIII WT	4.00 (0.22)	0.79 (0.03)	0.89 (0.11)	1.01 (0.11)	2.05 (0.20)	2.46 (0.19)	1.67 (0.30)	0.83 (0.12)
Db-DIII H535A	2.04 (0.08)	0.67 (0.05)	0.63 (0.05)	0.75 (0.06)	0.91 (0.08)	1.08 (0.11)	0.69 (0.12)	0.33 (0.03)
Db-DIII H510A	1.77 (0.14)	0.54 (0.06)	0.58 (0.03)	0.53 (0.08)	0.98 (0.07)	1.10 (0.07)	0.72 (0.14)	0.40 (0.02)
Db-DIII H464A	1.56 (0.15)	0.44 (0.06)	0.50 (0.07)	0.58 (0.08)	0.85 (0.12)	1.31 (0.15)	0.59 (0.06)	0.28 (0.03)
Db	0.08 (0.01)	0.19 (0.01)	0.10 (0.01)	0.33 (0.02)	0.10 (0.02)	0.52 (0.06)	0.04 (0.001)	0.03 (0.001)

Groups of four mice per protein were analyzed. Organ uptake is expressed as %ID/g [mean (SE)].