Table 1.

Power calculations for the JIA study

SNP	Locus	Allele frequency	Effect size (OR)	Power of JIA study (%)*
rs10910099†,‡	MMEL	0.66	0.9	53
rs11889341§	STAT4	0.22	1.12	48
rs7574865§	STAT4	0.22	1.17	76
rs8179673§	STAT4	0.22	1.13	55
rs10181656§	STAT4	0.22	1.13	55
rs13207033¶	TNFAIP3	0.79	0.86	67
rs6920220‡	TNFAIP3	0.22	1.22	93
rs42041**	CDK6	0.24	1.15	69
rs3761847§	TRAF1	0.43	1.11	55
rs10818488§	TRAF1	0.43	1.12	62
rs2900180§	TRAF1	0.35	1.17	86
rs2812378**	CCL21	0.34	1.12	59
rs4750316‡	PRKCQ	0.80	0.85	72
rs1678542‡	KIF5A	0.63	0.88	69
rs4810485**	CD40	0.75	0.84	84

Sample size, 1054 JIA cases and 3531 controls.

^*At α value 0.05, assuming a log-additive model;

^†SNP in r²=0.95 with the SNP associated with RA in the WTCCC study;

^‡Barton et al (2008)¹⁹;

^§Barton et al (2008)¹⁴;

^**Raychaudhuri et al (2008)²⁰;

^¶Orozco et al (2009) (submitted).

JIA, juvenile idiopathic arthritis; OR, odds ratio; RA, rheumatoid arthritis; SNP, single nucleotide polymorphism.