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Schematic representation of the GD-1 locus on chromosome 14. Using classical linkage techniques and whole-genome screening, we identified a major Graves' disease susceptibility locus on chromosome 14. This locus was named Graves' disease 1 (GD-1). The TSH receptor gene locus is between the sites A and B, from the two studies (32,39). This map also shows that the type 2 iodothyronine deiodinase gene (DIO2) is also very close to the TSHR gene at chromosome 14q31.
