Table 1.
Genomic polymorphisms |
Graves' disease |
Longevity |
Loss of photoperiod control (birds) |
Lower serum TSH |
Higher bone density |
Constitutively active mutations |
Congenital hyperthyroidism |
Toxic multinodular goiter |
Hot nodules |
Constitutively inactive mutations |
Congenital hypothyroidism |
Multinodular goiter |
Cold nodules |
Epigenetic suppression |
Thyroid cancer |
TSH, thyroid stimulating hormone.