Skip to main content
. 2010 Sep 7;5(9):e12170. doi: 10.1371/journal.pone.0012170

Figure 5. Effects of olprinone on nitrotyrosine formation and PAR.

Figure 5

Sections obtained from SCI animals demonstrate positive staining for nitrotyrosine (B) mainly localized in inflammatory, in Schwann cells in the white and gray matter. Olprinone treatment (0,2 mg/kg, 1 and 6 h after SCI induction) reduced the degree of positive staining for nitrotyrosine (C) in the spinal cord. PAR expression, as an indicator of in vivo PARP activation, revealed the occurrence of positive staining localized in nuclei of Schwann cells in the white and gray matter of the spinal cord tissues from mice subjected to SCI (E). Olprinone treatment reduced the degree of positive staining for PAR (F) in the spinal cord. Figures are representative of at least 3 experiments performed on different experimental days.