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. 2010 Sep 7;5(9):e12170. doi: 10.1371/journal.pone.0012170

Figure 10. Effects of olprinone on intrinsic apoptotic pathway.

Figure 10

SCI caused, at 24 h, an increase in Bax expression as evidenced by Western blot analysis (A). Olprinone treatment (0,2 mg/kg) reduced the degree of positive staining for Bax in the spinal cord (A). Moreover, a basal level of Bcl-2 expression was detected in spinal cord from sham-operated mice (B). Twenty-four hours after SCI, Bcl-2 expression was significantly reduced in spinal cord from SCI mice. Olprinone treatments (0,2 mg/kg, 1 h and 6 h after SCI induction) significantly reduced the SCI-induced inhibition of Bcl-2 expression (B).