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. 2010 Sep 7;5(9):e12170. doi: 10.1371/journal.pone.0012170

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Esposito et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Staining for Bax expression was absent in Sham group (A). Twenty-four hours after SCI, spinal cord tissue from injured-animals showed a positive staining for Bax (B). Olprinone treatments (0,2 mg/kg) significantly reduced the SCI-induced Bax (C). On the contrary, positive staining for Bcl-2 was observed in the spinal cord tissues from sham-operated mice (D) while the staining was significantly reduced in SCI mice (E). Olprinone treatment attenuated the loss of positive staining for Bcl-2 in the spinal cord from SCI- subjected mice (F). Data are expressed as% of total tissue area.