Figure 2. Structure of apicomplexan UDP-glucose/galatose pyrophosphorylase (UGGPase) as exemplified by Cryptosporidium parvum protein (CpUGGPase).
Sequence logos represent conserved motifs and domains as determined from 224 sequences of glucosyltransferase family-A (GTA) proteins including UGGPases and UDP-N-acetylglucosamine pyrophosphorylases (UAPs). In the fourth domain, UGGPases displayed a very unique sequence pattern that differs significantly from other GTA proteins. Stars indicate amino acids important at the active sites.