Figure 10. Effects of in vivo B₁R activation on superoxide anion production in the aorta of glucose-fed rats pre-treated or not with the NADPH oxidase inhibitor.

Basal and stimulated production of superoxide anion with the B₁R agonist Sar[D-Phe⁸]des-Arg⁹-BK (1 mg/kg, i.p.). Apocynin (50 mg/kg, i.p.) was administered 30 min prior to the B₁R agonist (see methods). Data are mean ± s.e.m of values obtained from (n) rats. Statistical comparison with glucose (+) or Sar[D-Phe⁸]des-Arg⁹-BK (†) is indicated by ⁺ P< 0.05, ^{++ ††}P< 0.01, ⁺⁺⁺P< 0.001.