Table 2.

Best 20 candidates of the prioritization (evaluation via similar phenotypes) of the chromosome X genes resequenced by Tarpey et al. (2009) (see also Supplementary Table S2)

Rank	Gene	Entrez ID	Disorder	Mut. score	Score sc
1	BRWD3	254 065	XLMR	2.86	7.16e-78
2	IRAK1	3654	–	1.94	1.84e-71
3	SYP	6855	XLMR	−	8.97e-69
4	BIRC4	331	other	37.04	4.28e-68
5	MAGED1	9500	–	5.14	5.63e-68
6	MORF4L2	9643	–	−	3.37e-66
7	ZNF280C	55 609	–	−	5.07e-65
8	SYN1	6853	XLMR	−	1.15e-64
9	CXorf6	10 046	other	12.00	1.19e-64
10	ATP6AP2	10 159	XLMR	−	2.70e-64
11	HCFC1	3054	–	27.82	1.65e-61
12	PJA1	64 219	–	2.44	1.82e-61
13	NGFRAP1	27 018	–	−	1.91e-61
14	FAM50A	9130	–	11.62	5.63e-61
15	HUWE1	10 075	XLMR	46.75	1.62e-60
16	GRIA3	2892	XLMR	13.00	1.14e-59
17	PIGA	5277	other	−	3.24e-59
18	OGT	8473	–	15.90	4.15e-59
19	GNL3L	54 552	–	22.49	1.68e-58
20	WDR40C	340 578	–	0.22	3.35e-58

Associations to disorders and mutation scores are as reported by Tarpey et al. Mutation scores reflect the conservation scores at missense positions and are summed over the single missense mutations found for each gene. Genes in bold face overlap with those in Table 3.