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Structures of AAG and APE1. (A) Space-filling representations of AAG bound to a 13mer εA-DNA [PDB entry 1EWN; (36)] and (B) APE1 bound to a 15mer abasic DNA [PDB entry 1DEW; (39)]. Protein surfaces are in red and DNA is in green. Both interact predominantly with one surface of the DNA. Therefore, it can be envisioned that both AAG and APE1 might simultaneously bind by interacting with opposing surfaces.
