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Chinese hamster Hprt gene and psoralen triplex target sequence. The position that varies between mouse and hamster genomes is shown (X:Y) as is the location of base analogues in the third strand (Z). Mutagenesis by a TFO-targeted psoralen cross-link (that links a thymine on each duplex strand) results in small deletions in the target sequence and adjacent exon 5. The frequency of mutations can be determined by quantitation of thioguanine resistant colonies.
