Skip to main content
. Author manuscript; available in PMC: 2010 Sep 7.
Published in final edited form as: Biochemistry. 2010 Sep 14;49(36):7867–7878. doi: 10.1021/bi100797z

FIGURE 4.

FIGURE 4

Analysis of second generation analogues. (a) Analogue structure. (b) Binding assay as in Figure 3b. (c) Thermal stability of triplexes with 2′-OMe third strands. (d) Thermal stability profile of AE-TFO-5a on the duplex target with A:T or C:G at the X:Y position. The thick arrow denotes the inflection for the triplex, while the thin arrow indicates that for the duplex. There is a single transition in the pattern with the C:G duplex as the triplex is more stable than the underlying duplex. (e) Thermal stability of triplexes with the 2′-AE cluster.